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, glutamate released during neurotransmission is primarily transported into astrocytes [52].Accordingly, astrocytes are neuroprotective [53,54] against neuronal glutamate toxicity.Although the average intracellular concentration of glutamate in the central nervous system (CNS) is greater than 10mM [55], extracellular concentrations in the low M range are toxic [56].Therefore all major CNS cell types contain high affinity glutamate transport mechanisms [57] which maintain extracellular concentrations at less than 1 M [55]

Autophagy suppresses tumorigenesis of hepatitis B virus-associated hepatocellular carcinoma through degradation of microRNA-224