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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal studies report wide therapeutic window Known interactions Methyl-donor depletion theoretical with chronic dosing (NNMT methylates nicotinamide using SAM) Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved

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doi:10.1007/s12070-018-1381-9 Mahalingam R, Wellish MC, Dueland AN, Cohrs RJ, Gilden DH

This is a protocol that normally produces robust tolerance