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Curcumin/piperine modulates the butyrate levels and alleviates diabetic kidney disease via Nrf2/HO-1 signaling pathway

Schlechter NL, Russell SM, Greenberg S, Spencer EM, Nicoll CS

These findings have been replicated in human skeletal muscle and cardiomyocyte models, where UA increases mitochondrial biogenesis through PGC-1 signaling (18)

2018, doi: 10.3390/ijms19123862

Chronic cadmium exposure triggered ferroptosis by perturbing the STEAP3-mediated glutathione redox balance linked to altered metabolomic signatures in humans