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Methyl donor supplementation reduces hepatic fat accumulation by activating the AMPK signaling pathway to increase fatty acid consumption

This mechanism helps mitigate diabetes-associated chronic inflammation at the molecular level (134)

Additionally, the article offers an overview of targeted drugs shown to be effective in cellular experiments, animal models, and clinical trials, analyzing their mechanisms of action and potential side effects

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10.3389/fimmu.2017.01096 175 SegawaS.WakitaY.HirataH.WatariJ