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10.1016/j.jneuroim.2021.577475 132 YangC.-C.LinC.-C.JouM.-J.HsiaoL.-D.YangC.-M

Aging Pathobiology and Therapeutics , 2020

Production of NAD+ declines sharply with age, leading to hidden cellular damage and visible symptoms like wrinkles, stubborn fat, cognitive fog, delayed recovery, and joint discomfort.[1][2][3] Emerging research suggests that this decline not only accelerates visible aging but also contributes to a cascade of metabolic and neurological issues, making NAD+ restoration a cornerstone of modern anti-aging protocols