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Other Safety Considerations Several additional safety topics are relevant to the clinical use of orforglipron: Gallbladder events: GLP-1 receptor agonists have been associated with increased rates of cholelithiasis and cholecystitis, likely mediated by rapid weight loss altering bile composition and gallbladder motility

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Early Signs and Symptoms of Vitamin B12 Deficiency: Fatigue, weakness, and lack of energy: These symptoms may be brought on by inadequate vitamin B12, which lowers the synthesis of red blood cells

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