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While there are several studies in mammals that reports link the GM with cognition, mental health and a range of physiological and pathological states (Tooley, 2020

Does weight gain associated with thiazolidinedione use negatively affect cardiometabolic health

Moreover, the pathological mechanisms of these endothelial injuries seem to be attributed to disorders of the NO/cGMP pathway, abnormal endothelium-derived vasoactive factors, oxidative stress, etc