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Description

Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types

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doi: 10.1016/s0015-0282(02)03133-3 252 AdvaniKBatraMTajpuriyaSGuptaRSaraswatANagarHDet al

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Together, these findings provide compelling evidence that oxidative stress plays a critical role in the pathophysiology of depression and may represent both a biomarker of disease severity and a potential target for therapeutic intervention through modulation of antioxidant defenses (3537)

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Injection site can still change the first few minutes of exposure because the area around the needle sees the highest concentration before dilution (subcutaneous absorption, injection-site PK)

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