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Additional cellular studies using mouse hippocampal HT-22 cells exposed to A1-42 oligomers have demonstrated that copper overload can promote A-induced neuronal damage via the NLRP3/caspase-1/Gasdermin D pathway (179,194)

doi: 10.3390/ijms17122093 39 GullyJ

Int J Radiat Oncol Biol Phys , 42:191203

Although some of these targets have not been confirmed, it still provides insightful information about how Grx2 may facilitate cellular survival and protection

This mechanism raises concerns about potential synergistic effects when co-administered with sedative-hypnotic medications, such as benzodiazepines or barbiturates, highlighting the need for caution