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ROS are mainly derived from the process of electron transfer from the mitochondrial electron transport chain complex to O 2 , with complexes I and II producing in the mitochondrial matrix and complex III producing in the matrix and membrane interstitium, which is the precursor of most ROS

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Indeed, the concentrations of all ETC complex inhibitors required to inhibit 50% of cancer cell growth were significantly reduced when cells were exposed to 5FU (Fig

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Hasenknopf, B