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In MS models, AST has demonstrated protective effects against demyelination by preserving oligodendrocyte viability and reducing inflammatory cytokine expression, both of which are critical in maintaining myelin sheath integrity ( Table 3, which highlights differences in study design, dosing regimens, and outcome measures

Researchers at the Broad Institute mapped its influence across over 4,000 human genes, finding a net shift toward younger expression patterns DNA repair genes up, inflammatory signals down

These compounds are divided into two classes: those with direct antibacterial activity are called antimicrobial non-antibiotics, while the second group consists of helper compounds and macrophage modulators.1820 The most well-known non-antibiotic compounds are phenothiazines,21 chlorpromazine, thioridazine,22,23 the anti-inflammatory drug diclofenac,24 antihistamines such as promethazine and diphenhydramine, and cardiovascular drugs such as amlodipine, dobutamine, lacidipine, nifedipine, and oxyfedrine.2527 The exact mechanism of non-antibiotic action has not been determined but they have been proposed to modify cell permeability and affect potassium and calcium efflux pumps in susceptible bacteria

F.et al (2021)