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The performance of each supervised model was estimated by evaluating the per cent of data variation explained (R 2 ) and the one predicted by according to cross-validation (Q2)

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(Luo et al., 2022) addressed this by using ECM-modified hydrogels (ECM-Gels) to load cartilage endplate stem cells (CESCs) overexpressing sphingosine kinase 2 (Sphk2)

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