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It differs significantly from traditional apoptosis, pyroptosis, and necrosis ( 2.2.1 Lipid peroxidation and Fenton reactions Lipid peroxidation is the core molecular event in ferroptosis ( 2.2.2 Glutathione Peroxidase 4 (GPX4) and its role in ferroptosis GPX4 is a selenoprotein that plays a central role in suppressing ferroptosis by catalyzing the reduction of membrane-bound phospholipid hydroperoxides (PL-OOH) into their corresponding non-toxic alcohols (PL-OH), thereby preserving lipid bilayer integrity under oxidative stress ( Beyond its classical enzymatic role, GPX4 is subject to multifaceted regulation

however, successfull delivery in clinical studies remains challenging [67] (Fig

Collection of bronchoalveolar lavage (BAL) fluid and lung tissue for protein and RNA Mice were euthanized via intraperitoneal injection of ketamine (130 mg/kg) and xylazine (8.8mg/kg) before euthanasia

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In addition, some bioengineered skin substitutes such as Dermagraft and Apligraf have been developed to accelerate the healing of venous ulcers (Nicholas 2016