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R., and Medina M., Fasentin Diminishes Endothelial Cell Proliferation, Differentiation and Invasion in a Glucose MetabolismIndependent Manner, Scientific Reports 10, no

METHODS DETAILS Data reporting The chosen sample sizes conform to those used in this field: n = 6-8 samples for determining the levels of GLP-1, insulin and glucose in mice

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muciniphila .175 As a result, the weakened gut barrier becomes more permeable, allowing bacterial toxins like LPS to enter the bloodstream, increasing inflammation and liver damage.175 Ethanol-fed mice and patients with alcohol use disorder (AUD) exhibit reduced numbers of macrophages in the duodenum and display dysregulated cytokine secretion and impaired phagocytosis.176 Moreover, reduced intestinal IgA secretion has been observed in patients with decompensated cirrhosis compared with those with compensated cirrhosis.177 Additionally, patients with AUD, even at precirrhotic stages, exhibit reduced intestinal T cell numbers and immune dysfunction, further exacerbating the risk of gut-derived liver inflammation.150 The interplay between bile acid (BA) metabolism and the gut microbiota is another critical factor in ALD