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Adverse Reactions / Side Effects Common (usually mild and self-limited): Flushing Headache Fatigue Nausea Metallic taste Injection-site pain (IV or IM) Rash or pruritus Moderate: Hypotension during IV infusion Diarrhea Dizziness Transient increases in liver enzymes Allergic reactions (urticaria) Serious (require immediate discontinuation): A

Subcutaneous administration (which bypasses first-pass metabolism and delivers more peptide to target tissues) was not extensively tested in human trials, and this route is what most current research protocols use

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CGI-58, the Causative Gene for Chanarin-Dorfman Syndrome, Mediates Acylation of Lysophosphatidic Acid

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