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the second domain which binds to an extracellular epitope of the human and/or the Macaca CD3 on the comprises a VL region comprising CDR-L1 , CDR-L2 and CDR-L3 selected from: the second domain which binds to an extracellular epitope of the human and/or the Macaca CD3 epsilon chain comprises a VH region comprising CDR-H 1 , CDR-H2 and CDR-H3 selected from: the second domain which binds to CD3 comprises a VL region selected from the group consisting of a VL region as depicted in SEQ ID NO: 17, 21 , 35, 39, 53, 57, 71 , 75, 89, 93, 107, 1 1 1 , 125, 129, 143, 147, 161 , 165, 179 or 183 of WO 2008/1 19567 or as depicted in SEQ ID NO: 13

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