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Chem Biol 11: 639646 Sedensky MM, Siefker JM, Morgan PG (2001) Model organisms: new insights into ion channel and transporter function

Therefore, elevated C3 can be an indicator of abnormal propionate catabolism

This review details the mechanisms and evidence of approved disease-modifying treatments, relevant measures to track disease burden and progression used in clinical trials, and approaches to pharmacologic management of common symptoms in ALS