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The accumulation of glucose and its metabolites in cells, for example in diabetes patients, enables this monosaccharide to interact with amino acid residues, which leads to the production of AGEs (168)

Deletion of protein tyrosine phosphatase, non-receptor type 4 (PTPN4) in twins with a Rett syndrome-like phenotype

Moreover, glycolysis induction is often accompanied by a repression in cellular respiration, oxidative phosphorylation (OXPHOS), making neoplastic cells less dependent on oxygen, as its availability can often be scarce in a growing neoplastic mass that is poorly vascularized [7]

The potential mechanisms such as enhanced tissue repair, angiogenesis, and anti-inflammatory effects certainly warrant further exploration in human medicine

MASLD was defined as hepatic steatosis, in the absence of heavy alcohol consumption (AUDIT 6oz animal protein (68% vs

doi: 10.3389/fphys.2022.840065 Received 20 December 2021 Accepted 31 January 2022 Published 24 February 2022 Volume 13 - 2022 Edited by John D