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Glucagon-like peptide-1 (GLP-1) agonists, initially indicated for treatment of T2D, are the newest FDA-approved AOMs

Acta 327 , 6979 (2003)

The simulated magnitude of the interaction (AUCR, 1.02) with midazolam was ~30% lower than observed (AUCR, 1.39) if only reversible CYP3A inhibition was considered, indicating that time-dependent inhibition contributes to the mechanism of the interaction