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Willauer AN, Liu Y, Pereira AAL, Lam M, Morris JS, Raghav KPS, Morris VK, Menter D, Broaddus R, Meric-Bernstam F, Hayes-Jordan A, Huh W, Overman MJ, Kopetz S , Loree JM

(87) used normal human lung fibroblasts (NHLF) and NS-398, a specific COX-2 inhibitor, to examine bystander effects and found that there were 4.2 1.2 bystander effect-induced mutations per 10 6 surviving cells in the control group, whereas bystander effect-induced mutations were reduced by more than 6-fold to 0.7 0.2 per 10 6 surviving cells in the NS-398-treated group (87)

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Functional pathway readouts as practical proxies Assays that quantify the activity of zinc-sensitive organelle pathways, such as secretory pathway processing, glycosylation capacity, UPR activation or lysosomal proteolysis, may provide clinically actionable proxies for luminal zinc availability and transporter performance

10.1212/wnl.51.6.1562 Neurology 53 MaJ.QianC.BaoY.LiuM.MaH.ShenM.et al (2021)

medial frontal lobe neurochemistry in autism spectrum disorder is marked by reduced N-acetylaspartate and unchanged gamma-aminobutyric acid and glutamate + glutamine levels