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Although the flavourings used have been proven to be safe when used in food, that does not necessarily mean they are safe for other uses, such as in e-cigarettes

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However, as of 2021, e-cigarette use among Americans aged 5064 and 65 years is 2.9% (95% CI 2.3, 3.5) and 0.9% (95% CI 0.6, 1.2), respectively, compared to 10% for those aged 1834 years [23]