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Natl Sci Rev 2020b;7:67185

Most studies depend on 2D cell models that overlook intratumoral redox heterogeneity, while quantitative correlations between nanoparticle degradation and intracellular GSH dynamics are limited

Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer