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Hepatoma cell lines typically lack the CYP450 activity to generate the reactive metabolite of APAP observed in vivo, but are still subject to APAP cytotoxicity

non-motor symptoms include autonomic dysfunction, sleep disorders, cognitive abnormalities, and constipation, see the reviews by Most PD cases are sporadic and approximately 10% of cases are inherited (Yoo et al., 2018)

Briefly, G401 cells were seeded into 96-well plates at a density of 1 10 4 cells/well, and the measurement was performed at 24, 48, 72 h after seeding