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However, as this model does not fully recapitulate the patterns of cocaine and nicotine use that humans with CUD display, future preclinical examinations of polysubstance use in the context of CUD would benefit from polysubstance versus cocaine alone choice procedures to enhance translational validity, and from application of behavioral economics approaches to examine individual differences in consumption and motivation for cocaine + nicotine

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There was no significant difference in cancers, though the study didnt specifically look at lung cancer

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