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Glutathione S-transferase activity was measured as described by Habig et al

This immunomodulatory enzyme, generated by M2 (alternatively activated) macrophages and other immunoregulatory cells, plays a distinctive role in restricting diseases associated with inflammation, particularly in immune-privileged tissues such as the eyes [39,40,41]

This effect, combined with an anti-androgenic action at receptor sites (pharmacological toxicity), can result in gynaecomastia and decreased libido

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