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Aging-associated metabolic shifts, including acidosis and reduced red cell 2,3-BPG content, can alter oxygen release at the tissue level, compromising cellular respiration even when total hemoglobin levels are within normal ranges

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Interestingly, FADS2 has been shown to be a ferroptosis inhibitor [160]

Both exercise testing visits consisted of three treadmill runs to volitional fatigue at 90%, 100%, and 110% of the peak treadmill speed that was determined by peak velocity (PV) from the maximal oxygen consumption (VO2max) test during visit one