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J Clin Invest 111(8):11221124

J.BensonH.et al (2016)

Through the presence of divalent metal transporter protein 1 (DMT1, also known as soluble protein carrier [SLC11A2]) and ZRT,IRT-related protein 14 (ZIP14, also known as SLC39A14), Fe 2+ can be transferred into the cytoplasm as an unstable iron pool (LIP) (72)

For instance, a high glycolytic state (high lactate) might shift the balance from acetylation to lactylation on certain histones, potentially altering promoter and enhancer activity in ways that we are just beginning to understand 42