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The concentrations of NAC that inhibited and killed the bacteria of the NT Hi biofilms are similar to those that are theoretically obtained in oropharyngeal secretions during normal oral NAC treatment with 200600 mg tablets taken two or three times daily 63

Glutathione is involved in many cellular processes

This clusterzyme could fully exploit the nutrient-rich oral environment to convert nontoxic glucose into highly toxic OH via a cascade catalytic reaction, thus impeding and eliminating biofilm induced by F

Additionally, activated platelets exhibit catalytic activities by assembling coagulation factors on their surface (78).The main mechanisms of microvascular thrombosis in COVID-19 associated SPG were summarized in Figure 2