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Glutathione represents the most abundant intracellular antioxidant capable of (i) directly interacting with free radical species, (ii) revitalizing other small molecule antioxidants (e.g., vitamins C or E), (iii) maintaining the redox state of protein thiols, and (iv) serving as a cofactor for enzymes of the cellular antioxidant system (Espinosa-Diez et al

Moreover, functionalized NPs can act as contrast agents in imaging techniques, selectively accumulating in affected brain areas to enhance disease detection and monitoring (126)

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Dichloroacetate (DCA): This small molecule inhibits pyruvate dehydrogenase kinase, promoting pyruvate entry into mitochondria and favoring OXPHOS over glycolysis

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Iron accumulation drives the Fenton and Haber-Weiss reactions, generating ROS that induce lipid peroxidation, leading to oxidative damage to subcellular structures (88)