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This stability can be attributed to a hydrophilic PEG layer surrounding the NPs, which acts as a steric hindrance to prevent non-specific adsorption and aggregation

In addition, gene therapy, exosomes, and tissue engineering also provide new directions for ocular drug delivery

PloS One (2016) 11(9):e0162734

While some modern formulations use specialized delivery systems to help it sink in, much of a standard topical cream may simply sit on the surface

Peptide release analysis The transdermal diffusion of IM2 and NE1 was studied using Phoenix Dry Heat Systems