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The equilibrium between physiological and pathological angiogenesis is mediated by the communication of numerous endogenous angiogenic and anti-angiogenic modulators

Bursill CA, Castro ML, Beattie DT, Nakhla S, van der Vorst E, Heather AK, Barter PJ, Rye KA

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By inhibiting Aurora-A, Aurora-B, and Aurora-C kinases, these compounds induce defects in mitotic spindle assembly, causing temporary cell cycle arrest and disrupting proper chromosome alignment during mitosis [78]

Ideally, the targeted receptor- or carrier-mediated transport processes for brain targeting should occur exclusively at the BBB to avoid off-target delivery