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This can be accomplished by any of numerous methods known in the art, e.g., by constructing them as part of an appropriate nucleic acid expression vector and administering it so that they become intracellular, e.g., by infection using defective or attenuated retrovirals or other viral vectors (see U.S

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Dopaminergic neuron-specific elimination of OGT caused early loss of axonal arborization and premature neurodegeneration, whereas enhancement of O-GlcNAcylation by knocking out OGA in dopamine neurons did not negatively affect neuronal structures

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