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Excessive lactate accumulation acidifies the TME, impairing T and NK cell function while promoting immunosuppressive phenotypes such as M2 macrophages, ultimately fueling ICI resistance

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Hariz MI, Johansson F, Shamsgovara P, Johansson E, Hariz GM, Fagerlund M (2000)

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doi: 10.1016/j.biocel.2005.03.005 18 DriverB.MarksD

NAFLD has become increasingly common in the UK, affecting approximately one in three adults, often associated with obesity, type 2 diabetes, and metabolic syndrome