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Effects of cigarette smoke extracts on the growth and senescence of skin fibroblasts in vitro

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However, cigarette smoking remains a leading cause of preventable death in Canada [2] and around the world accounting for more than 4 million deaths each year worldwide [3]

Traditional cigarettes also produce higher levels of carbon monoxide and oxidant gases, leading to oxidative stress and reduced oxygen availabilityfactors that pose significant cardiovascular risks (Hutzler et al., 2014

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