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L-Glutamine supplementation is mostly recommended to: Sickle cell disease patients Cancer patients who are under chemotherapy Critically ill patients with too low L-glutamine in the body after trauma or surgery Individuals who are experiencing leaky gut syndrome or inflammatory bowel disease Athletes or fitness enthusiasts who engage in high-impact exercises, prolonged intense training, which depletes L-glutamine stores

Mechanism gaps Despite four decades of research, DSIP precise mechanism of action remains unclear

instead, another crystalline component, the EDTA-Na salt, was identified (Figure 6A)

Int J Mol Sci 25:7037

The findings collectively indicated an absence of dose-dependent efficacy for IVIG in CFS, and did not support its use as a standard therapy for this condition [104]