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The exceptional in vitro potency is attributed to its mechanism of acting as an allosteric potentiator of HGF binding to c-Met (amplifying an endogenous signal), which produces non-linear dose-response curves

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Fortunately, DSIP has already been used in experiments involving human subjects as early as the 1980s for this very purpose

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there have been no reports of organ damage or severe reactions directly linked to NAD+ in clinical studies