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Endogenous purines originate from nucleic acid breakdown of damaged/apoptotic cells, along with adenine and guanine degradation, whereas exogenous purines are primarily derived from dietary sources, including fructose-rich beverages and purine-rich foods (e.g., meat and seafood) (Weaver, 2019)

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11 Further research identified the NADPH oxidase (NOX) system as a critical source of H 2 O 2 in cells, including non-phagocytic ones, emphasizing its signaling role under physiological conditions

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Furthermore, intracerebroventricular infusion of MCH caused induction of hepatic steatosis and increase in body weight (prominent aspect) in high-fat diet-fed wild-type mice (Kawata et al., 2017)