melanotic macule palate Pigmented Lesion on the Hard Oral melanotic macule - Stock

Partial List The Times of India and Corriere della Sera, Italy

Melanin pigmentation has been reported to be most intense at the tips of the rete ridges [31, 34]

This chromatic variability not only reflects the genetic factors that regulate melanin synthesis by melanocytes and its subsequent transfer to adjacent keratinocytes but is also influenced by external factors such as trauma, inflammation, hormonal fluctuations, exposure to certain pharmacological agents, external agents that can pigment the mucosa, and radiation, all of which can induce an increase in melanin production

That means tumor recurrence is unlikely after the treatment

The underlying dermis does not exhibit a host response

These UV-independent melanogenesis studies have established MT-1 as the reference tool for dissecting MC1R-specific pigmentation biology from UV-dependent mechanisms