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Also, itaconate is increasingly produced by macrophages with a disrupted TCA cycle - as shown upon LPS stimulation (Strelko et al., 2011) - but triggers subsequently protective effects, e.g., by the inhibition of succinate dehydrogenase (which controls levels of pro-inflammatory succinate), glycolysis and pro-inflammatory NLRP3 inflammasome activation (Strelko et al., 2011), whereas activating the anti-inflammatory transcription factors NRF2 and ATF3 (Peace and ONeill, 2022)

Genetic drivers such as TP53 loss or breast cancer gene 1 (BRCA1) mutations not only promote genomic instability but also elevate the cellular ROS set-point, forcing the tumor to adopt robust antioxidant adaptations that are absent in infiltrating immune cells [91, 92]

The water matrix may contain constituents such as TOC, TSS, and TDS at levels that may require pretreatment because they could interfere with and reduce the effectiveness of the PFAS treatment technologies

et al., 2019), and kudzu polysaccharides may treat diabetes by modulating the PPAR signaling pathway and the structure of intestinal flora (Wang et al., 2022)

Carter BZ, Mak PY, Ruvolo V, Tao W, Hughes PE, Chen X, Morrow PK, Andreeff M

(A-C) Reproduced with permission Copyright 2025, Biosensors and Bioelectronics [25]