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Complex IV-deficient Surf1 / mice initiate mitochondrial stress responses

Journal of Biological Chemistry 279: 778591

Addressing these areas will not only deepen the understanding of ferroptosis in RCC but also accelerate the translation of ferroptosis-targeted strategies into effective, personalized therapies for this lethal disease

While more studies are needed, these findings suggest that the airway GSH/GSSG redox balance may lead to induction of glutathione peroxidase transcription, protein expression, and secretion and activation in the airway

Docking simulation of (2 S ,3 S )- t -ES-l-Phe ( 15 ) with Cp1B showed that the side chain of l-Phe can also be housed in the same hydrophobic pocket, suggesting that the MES-binding site could be where the side chain of the l-amino acid binds (Supplementary Fig

In contrast, in plasma the reverse is true and cystine levels are present at higher concentrations, highly oxidized and the main indicator of an increased oxidation state due in part to the oxidizing impact of the plasma on thiols (Turell et al., 2013)