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MSU crystals activate the Mitogen-activated protein kinase (MAPK)/NF-B and Janus kinase-1 (JAK-1) - signal transducers and activators of transcription1/3 (STAT1/3) signaling pathways in macrophages, inducing M1 macrophages polarization and releasing M1 macrophages-associated factors TNF, IL-1, and IL-6 (66, 70)

Yellow stool is usually the result of excess fat in the stool

These viral mimetic NPs do not have immunogenicity and could efficiently deliver genetic material to the brain by exploiting natural cellular uptake processes

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