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Apart from ROS being created as a result of oxidative glucose metabolism, the constant exposure of retinal cells to sunlight and artificial light triggers the production of ROS 16,17 , especially with photosensitizers present, such as retinoids 16,18 , and leads to photo-oxidation 19

Since THC is lipophilic and binds to fat cells, alcohols interference with fat metabolism further complicates the release and elimination of stored cannabinoid metabolites from adipose tissue