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Finally, cereals contain a series of biologically active components (tocotrienols, folates, beta-glucans, fructans, lignans, polyphenols, phytosterols, policosanols) capable of exerting antioxidant and prebiotic activities, albeit in small quantities [138]

The TGR inhibitor demonstrating greatest efficacy in treating infected mice, 2 , was also studied after oral administration: 2 (200 mg/kg p.o.) gave plasma concentrations of 0.71, 0.77, and 0.40 M at 30, 60, and 120 min, respectively (Supplementary Table 19)

In addition, these compounds inhibited IL-1 secretion from monocytic cells

doi: 10.1046/j.0022-3042.2002.00779.x 142 LimC