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Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )

Willis, C

Asgharpour A, Cazanave SC, Pacana T, Seneshaw M, Vincent R, Banini BA, Kumar DP, Daita K, Min HK, Mirshahi F, Bedossa P, Sun X, Hoshida Y, Koduru SV, Contaifer D Jr, Warncke UO, Wijesinghe DS, Sanyal AJ (2016) A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

Keywords Reactive nitrogen species, reactive oxygen species, endoplasmic reticulum stress, unfolded protein response, drug-induced liver injury Introduction Drug-induced liver injury (DILI) plays an essential role both in the clinic and in drug development [1]

[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Nunn AVW, Guy GW, Botchway SW, Bell JD

The interplay between microglial function and systemic metabolic states is gaining increasing attention