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Vitamin B12 absorption occurs primarily in the terminal ileum through intrinsic factor-mediated absorption (for both dietary and supplemental B12) and passive diffusion (particularly relevant for high-dose supplements)

125 Not only is the TSC1TSC2 complex maintained in its active form (phosphorylation of TSC1) by AMPK, but it is also activated by the REDD1 (regulated in development and DNA damage responses 1) protein, itself activated under hypoxic condition

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DAPI dye solution was added to the sections, which were incubated at room temperature for 10 min in the dark and then washed