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Large meals overwhelm a stomach that is emptying more slowly due to GLP-1 activation

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A conservative approach using 0.25 mg daily for the first two weeks allows assessment of individual response before considering increases

Splitting vials across titration phases Some researchers reconstitute their 10 mg vial at a higher concentration (5 mg/mL with 2 mL water) for the later phases when precision is less critical and injection volume matters more

Mice were maintained on a standard diet, and water was freely available