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Alongside pharmacological chelation, natural methods have also been shown to support the elimination of toxic metals

Insufficient sleep can cause increased cytokine secretion provoking an inflammatory response in various tissues including the brain which is associated with cognitive impairment [2]

Circulating NEFA concentrations are regulated by a balance between catabolic processes in adipose tissue and fatty acid substrate utilization by the skeletal muscle

N-acetylcysteine (NAC) is a stable, safe and highly bioavailable antioxidant that shows promising prospects in bone tissue engineering due to the ability to attenuate oxidative stress and enhance the osteogenic potential and immune regulatory function of cells

However, while p53 modulates SLC7A11 expression, the expression and activity of SLC7A11 and GPX4 are not associated with SAT1, and only ferrostatin-1 can inhibit ROS-induced ferroptosis in Tet-on cells (Ou et al., 2016)

Table 5 Randomised and controlled clinical trials evaluating antioxidant supplementation in breast cancer prevention, adjuvant therapy, and supportive care