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220 HIF-1 interacts with BCL2, BNIP3, BNIP3L/NIX, Beclin-1, ATG proteins, and PIK3C3 to stimulate autophagy, 221,222 while AMPK and PTEN suppress mTORC1, activating ULK1 and enhancing autophagosome-lysosome fusion

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Soluble proteins like antibodies, which remain exposed beyond the detergent micelles, aid in crystal formation

The top 16 gut bacterial taxa whose relative abundances changed significantly in both RBD-PD and iRBD patients were identified by simultaneously satisfying p 1.5 in both the RBD-PD vs

Second, the controlled injury stimulates fibroblasts, the cells responsible for producing new, healthy collagen