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Clin Chem Lab Med

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Knockout of the de novo DNA methyltransferase DNMT3A in human induced pluripotent stem cell (iPSC)-derived cardiomyocytes within engineered heart tissues (EHTs) causes mitochondrial dysfunction, impaired glucose metabolism, and intracellular lipid accumulation under baseline conditions

Generative AI statement The author(s) declare that Gen AI was used in the creation of this manuscript

Research applications include investigations into NAD+ metabolism, mitochondrial function, and metabolic adaptation.