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Destabilizing mutations facilitate this initial transition, and the increased rate of conversion to a pathological state likely contributes to the earlier age of onset compared with wild-type TTR amyloidosis

Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria

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Similar content being viewed by others Introduction Immunosenescence, a concept proposed by Roy Walford in the 1960s, refers to the progressive remodeling and decline of immune function with aging